EXCLUSIVE: Parkinson's link to statins: Calls to end widespread use of the drug - Parkinsons

EXCLUSIVE: Parkinson's link to statins: Calls to end widespread use of the drug

PLANS for the mass prescription of statins should be shelved after a study linked the drug to Parkinson’s disease, an expert last night warned.

Published: 08:43, Sun, March 8, 2015

By LUCY JOHNSTON

Dr Kailash Chand, deputy chairman of the British Medical Association, was speaking following research which found those who take the cholesterol-lowering drugs are more than twice as likely to develop Parkinson’s disease in later life than those who do not.

A study last week showed statin use increases the risk of diabetes by 46 per cent.

It has led to calls to end to the widespread use of the drugs.

"The risks of side-effects of these drugs are far greater than any potential benefits and it is high time these drugs were restricted in the low-risk population"

Dr Kailash Chand

The Parkinson’s research carried out over 20 years, and involving nearly 16,000 people, suggests cholesterol may have a vital role in protecting the brain and nervous system.

The findings have alarmed experts who say if applied to the number of Britons deemed eligible for statins it could equate to 150,000 extra patients with Parkinson’s, a central nervous system disorder affecting one in 350 mostly older people.

The work has also fuelled concerns that statins, now recommended for up to half the adult population over 50 by government drug policy adviser the National Institute for Health and Care Excellence, may be doing many patients more harm than good.

Doctors used to prescribe the drugs only to those who had a 30 per cent or greater risk of suffering a heart attack within a decade, but this was lowered to 20 per cent in 2005.

A 10-year plan has been introduced to reduce this further and include low-risk patients who have just a 10 per cent chance of a heart attack within a decade.

Nice believes this could save thousands of lives.

Other studies have shown a link between the cholesterol-lowering drugs and potentially disabling side effects including cataracts, diabetes, muscle pains, fatigue and memory loss.

GETTY

Researchers warn that the mass roll-out of statins leaves 150,000 people at risk

Dr Chand, who suffered debilitating muscle pains while taking statins, said of the Parkinson’s research: “This research has been done over a considerable amount of time and on a considerable number of people and it is very worrying.”

Speaking in a personal capacity, he added: “The risks of side-effects of these drugs are far greater than any potential benefits and it is high time these drugs were restricted in the low-risk population and only given to people with existing heart disease.”

Dr Xuemei Huang, who led the research on the link with Parkinson’s disease, recently published in the journal of Movement Disorders, expressed concerns about the widespread prescription of statins.

Related articles

• How statins can cause diabetes: Pills raise the risk of getting disease by 46 per cent
• Cholesterol and death certificates: Doctor Rosemary Leonard answers your medical queries
• EXCLUSIVE: Statins expert calls for safety checks over the drug

The professor of neurology at Penn State College of Medicine in Pennsylvania said: “If we blanket prescribe statins to people we could be creating a huge population of people with neurological problems.

“Does mother nature create cholesterol for a reason?

"I think doctors are over-enamoured with statins and think it is a cure-all.

“But the body is not just for the heart, it is also for the brain.

"It is potentially harmful for these drugs to be given out so widely and randomly.”

Last year leading doctors’ magazine Pulse revealed two-thirds of GPs are disregarding Nice advice to offer statins to more patients. 

Early Signs of Parkinson's Disease

Early Signs of Parkinson's Disease

Degenerative diseases such as Alzheimer's and Parkinson's represent some of the largest challenges facing medical researchers today. These diseases not only rob us of control over our own bodies, but slowly sap our mental capabilities as well. Like most diseases, however, they are best detected early on, when we can at least slow down the progress of the disease, hopefully until better treatments are found. To do this, we must be aware of the early symptoms and signs that point to Parkinson's. Note: Don't panic if you have one or more of these symptoms, as they can be related to other issues. However, to stay on the safe side, if you think there is even a small chance you are showing early signs, please get tested, if only for your own peace of mind. If you do have it and you catch it early, the prognosis will be much better for you. Here are 8 early symptoms of the onset of Parkinson's disease.

1. A change in handwriting If a person's handwriting starts to go from big and free to small and cramped, this may well be an early sign of Parkinson's. The telling signs are letters that get smaller and words that seem crowded together with letters almost written on each other. Many patients also take longer to write and have trouble with repetitive tasks. 2. A reduced sense of smell If someone is suddenly having trouble smelling pungent foods or picking up on scents, they should go see a doctor. Most times it has to do with sinuses, and it's definitely not one of the most obvious signs of Parkinson's, but doctors say patients with Parkinson's claim it is the earliest sign they had of the disease. While studies haven't proven the link between the symptom and the disease, a working theory is that certain proteins form clumps in the brain and may form in the olfactory area, reducing our sense of smell. 3. Trouble sleeping Another symptom that can be easily ignored because it's so common, is the sudden inability to sleep well, even if you're usually a sound sleeper. Suddenly you toss and turn, your limbs move and twitch during sleep, or you may even wake up on the floor, having fallen from bed. Ask your significant other if you are making a lot of movements at night, and go see a doctor if it persists.  4. A quieter, softer voice or an expressionless face A softer voice and a masked face are common signs of Parkinson's. Some will not notice they are speaking at a softer tone, and they definitely won't notice their face losing expression, so it is up to the people around them to be aware of these signs. Speaking too rapidly or stammering a lot is also a symptom.  5. Depression Obviously many patients develop depression after learning they have Parkinson's, but there is a physical link between the deterioration that comes with Parkinson's and depression. Some patients get depressed years before the other symptoms of the disease appear. Lower-than-normal secretions of serotonin and dopamine, the neurotransmitters involved with many bodily functions as well as mood, can cause this effect. 6. Constipation If you find that you've seriously reduced the number of times you move your bowels, sometimes even skipping a day - that's not a good sign, even if it's not Parkinson's, and so you should check it out. The disease has an effect on the autonomic nervous system, which is responsible for unconscious processes such as digestion and bowel function. Constipation on its own is usually nothing to worry about, but if it comes with some of the other symptoms on this list - go get checked immediately.   7. Shaking / tremors while perfectly relaxed Shaking is perfectly normal under certain circumstances. We may be excited or anxious, have just finished a workout or are feeling restless. But small shakes in our fingers, our hands, our chin, lip or full limbs while we're at rest could be a strong sign of Parkinson's, according to the National Parkinson Foundation. This symptom appears in about 70% of patients and can become more noticeable during stress or excitement. This symptom usually arrives AFTER the other symptoms on this list though. However, many a time it is the first one truly noticed, as the others can all have other explanations.  8. Stiffness and slowness of movement Stiffness in the joints that doesn't go away, coupled with muscle weakness that's here to stay can spell bad news. Suddenly everyday tasks like buttoning your shirt, walking or fixing things around the house become bothersome and difficult. You stop swinging your arms as you walk and your legs and feet feel heavy and 'stuck to the floor'. If you start hesitating before taking steps, or people are commenting that you look stiff or sore - please see a doctor.